CASPER: Calcium algorithm aortic valve raphe
Research type
Research Study
Full title
CASPER: Calcium Algorithm Sizing for bicusPid aortic valve Evaluation (+/- Raphe)
IRAS ID
306249
Contact name
Christopher Malkin
Contact email
Sponsor organisation
University of Pisa
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 8 months, 31 days
Research summary
Trans-catheter aortic valve implantation is widely used to treat aortic stenosis in patients over 70 years of age. Approximately 10-15% patients have bicuspid aortic valves and there is no widely recognised algorithm to choose valve size and type for these patients. CASPER is a specific algorithm based on size of the aortic annulus, volume and distribution of calcium and shape of the fused leaflet that has been found helpful. This study is a descriptive evaluation of the CASPER algorithm on valve outcome and performance. \nClinical outcomes (death, stroke, bleeding) and Valve outcomes (relief of aortic stenosis and valve leak) are recorded. An additional CT scan is performed after the TAVI procedure to evaluate the shape and position of the valve in reference to what was predicted by CASPER algorithm
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
23/NW/0051
Date of REC Opinion
10 May 2023
REC opinion
Further Information Favourable Opinion