Case-control study of inherited women's cancer
Research type
Research Study
Full title
Case-control study of individuals with increased risk of inherited women's cancer
IRAS ID
53431
Contact name
Martin Widschwendter
Contact email
Sponsor organisation
JointUCL Research Office (part of the Research Support Centre)
Eudract number
NA
Research summary
Every day, 20 women are diagnosed with ovarian cancer in the UK. Of those, less than 7 will survive beyond 5 years. Similar figures exist for triple negative breast cancers, which in fact share similar expression and copy-number variation profiles (The Cancer Genome Atlas Research Network, Nature, 2013).
About 5-10% of all breast and ovarian cancers, in particular those that are difficult to treat (high grade serous ovarian and triple-negative breast cancers and serous endometrial cancer), arise in women with a germline mutation in the BRCA1/2 gene. Only about half of these women would be identified due to their family history.
We aim to recruit a cohort of volunteers with confirmed BRCA/Lynch Syndrome mutation carrier status (with confirmed non-carriers as controls) in order to contribute substantially to the elucidation the process of cancer development in women with inherited risk of ovarian and breast cancer in order to identify minimally invasive biological markers that would aid the diagnosis of individuals at risk of breast, endometrial and ovarian cancer; and to identify molecular targets to prevent the development of inherited women's cancer.
REC name
London - Surrey Borders Research Ethics Committee
REC reference
14/LO/1633
Date of REC Opinion
27 Oct 2014
REC opinion
Further Information Favourable Opinion