CARDIUM
Research type
Research Study
Full title
Cardiac Failure Investigation Network-Understanding Mechanisms (CARDIUM); a study to understand the aetiololgy and prognosis of heart failure.
IRAS ID
209710
Contact name
Reecha Sofat
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2016/10/46 , UCL Data Protection Registration Number
Duration of Study in the UK
10 years, 0 months, 1 days
Research summary
Heart failure is a disease that affects over 900,000 people in the UK and more than 23 million worldwide. Incidence and prevalence increase with age, and are expected to rise in line with an ageing population. It has a poor prognosis, with 30-40% of all newly diagnosed patients dying within a year, and consists of signs and symptoms that result from the pumping action of the heart working less efficiently. The mainstay of treatment is with medication, which acts to control blood pressure and improve the pump function of the heart. Care costs include hospitalisation for acute decompensation, morbidity associated with symptoms of the disease and ongoing medication. While the majority of cases of heart failure in the UK are due to ischaemic heart disease, there is a significant proportion that are due to heart valve problems, cardiomyopathy due to inherited or drug-related causes such as cancer treatments and alcohol and irregular rhythms of the heart. Historically, heart failure was thought to be well understood within these categories. However, estimates of the risk of each of these causes may be in some cases overestimated, such as that for ischaemic heart disease, and underestimated in others, such as in patients with diabetes. In diastolic heart failure, or heart failure with a preserved ejection fraction, the risks for these causes are not understood well at all. For all types of heart failure, treatments are largely based on controlling maladaptive physiological processes, regardless of the cause. The aim of the heart failure case collection, CARDIUM, is to understand and target the cause of heart failure,with the aim to provide treatment strategies earlier on in the disease process, and to allow a stratified approach to approach to clinical management.
REC name
London - Queen Square Research Ethics Committee
REC reference
17/LO/0079
Date of REC Opinion
30 Jan 2017
REC opinion
Favourable Opinion