CARDIOFLOW study

• Research type

  Research Study

• Full title

  Assessing the efficacy of CARDIOgoniometry (CGM) to determine physiologically significant stenosis in patients with stable coronary artery disease in comparison to FLOW fractional reserve – CARDIOFLOW

• IRAS ID

  173201

• Contact name

  Angela Hoye

• Contact email

  angela.hoye@hull.ac.uk

• Sponsor organisation

  Hull University Teaching Hospitals NHS Trust

• Duration of Study in the UK

  0 years, 11 months, 31 days

• Research summary

  The CARDIOFLOW study compares two tests for assessing the severity of your angina to learn which one is better. Angina is a condition in which there is a narrowing of one of your hearts blood vessels which reduces blood flow to your heart muscle and limits how much oxygen can get to your heart (also called ischaemia).
  Sometimes when we do a special x-ray of your heart called a coronary angiogram, it may appear that one of your heart blood vessels is narrowed but the restriction on blood getting passed the narrowing may not be as severe as it looks. There is a special test we can do to assess how much of an impact this narrowing is having on blood getting passed it called fractional flow reserve (FFR), where a wire is passed down your blood vessel to measure the pressure. However this is invasive and expensive so we want to see if another test called cardiogoniometry (CGM), which is not invasive and cheaper, is as good as FFR at detecting the impact the narrowing in your blood vessel is having.

  This question has not been answered before and it is important to know if this test could be clinically useful in investigating patients with angina. We aim to have 30 patients in this study, every one of them with at least one such narrowing in the blood vessel for which pressure wire study is deemed a requisite to decide about the significance.

  The cardiology department at Castle Hill Hospital currently undertakes approximately 200 FFR procedures per year. We anticipate that based on the above inclusion and exclusion criteria at least 50% of these patients would be potentially suitable for enrolment and therefore are confident that we will be able to recruit the 30 patients required.

• REC name

  Yorkshire & The Humber - Bradford Leeds Research Ethics Committee

• REC reference

  15/YH/0271

• Date of REC Opinion

  13 Jul 2015

• REC opinion

  Further Information Favourable Opinion