Cardiac work & Right ventricle Strain In Sepsis (CRiSIS)
Research type
Research Study
Full title
Can changes between days 1 and 3 in cardiac work and right ventricle free wall strain predict 30-day mortality in critical care patients presenting with sepsis?
IRAS ID
262520
Contact name
Theophilus/TL Samuels
Contact email
Sponsor organisation
Surrey and Sussex Healthcare NHS Trust
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
1 years, 3 months, 0 days
Research summary
When the body’s response to infection becomes exaggerated, the condition is described as sepsis and can result in damage to organs, such as the heart and kidneys. We know that the heart can undergo a massive insult during sepsis and may take up to 10 days to fully recover once the patient has been successfully treated. Much work has been done to study the left ventricle (the main chamber of the heart) in sepsis, and in this pilot study we will add to the knowledge of what happens on the right side of the heart during sepsis. We hope this will lead to improvements in care for patients with sepsis.
We will be looking at the energy spent by the heart to pump blood around the body and the stress placed on the right heart to pump blood through the lungs in sepsis, and whether this can help us predict mortality 30 days or 90 days after being admitted to intensive care. We would like to develop a predictive model that we could test in a larger study.
We can do this using ultrasound, which uses sound waves to produce pictures of structures within the human body; the same technology used to produce an image of a mother’s baby during her pregnancy. When we use this technology to visualize the heart, it is known as echocardiography. In addition to performing a routine echocardiogram when the patient is admitted to ICU, we will repeat the scan on day 3 and day 90 and use specialised software to calculate the energy spent and the stress placed on the heart.
We aim to enrol at least 100 patients from Surrey and Sussex Healthcare NHS Trust intensive care unit over a 12 month period, since we treat between 300-400 patients per year with sepsis.
REC name
London - Bromley Research Ethics Committee
REC reference
21/LO/0303
Date of REC Opinion
12 May 2021
REC opinion
Further Information Favourable Opinion