CApture of Prostatic Transrectal Ultrasounds for REsearch (CAPTURE)

  • Research type

    Research Study

  • Full title

    Capture of Prostatic Trans-rectal Ultrasound scans for REsearch into improved targeted biopsy techniques. (CAPTURE)

  • IRAS ID

    228575

  • Contact name

    David Thurtle

  • Contact email

    dt433@cam.ac.uk

  • Sponsor organisation

    Cambridge University Hospitals NHS Trust

  • Clinicaltrials.gov Identifier

    A094516, Cambridge University Hospitals NHSFT R&D Reference Number; HVM/2017/2012, University of Cambridge

  • Duration of Study in the UK

    5 years, 0 months, 0 days

  • Research summary

    Prostate cancer (PCa) is the commonest male cancer in the Western world. The most common method of diagnosing prostate cancer is with a needle biopsy of the prostate guided by an ultrasound probe inserted into the rectum. With recent advances in magnetic resonance imaging (MRI), detection of clinically relevant prostate cancer can be better-achieved using targeted approaches. This is done most accurately by image fusion techniques. However this currently requires expensive and cumbersome equipment, and usually for the patient to receive a general anaesthetic.
    Ground-breaking work in Cambridge has led to the development of the CamProbe device which enables free-hand trans-perineal prostate biopsy under local anaesthesia. Alongside this, there is a critical need for a simplified tool that can enable targeted biopsies. In this study we are seeking to address this by collecting ultrasonic recordings of the prostate. These will facilitate research using computational and mathematical modelling to develop novel anatomical registration techniques for real time image-fusion guided biopsies.
    Men already undergoing transrectal ultrasound and transperineal biopsy under general anaesthesia will be consented for an additional trans-rectal ultrasound to be performed whilst under anaesthesia. The additional ultrasound recording will be purely observational, with no additional biopsies, and no change to the patient’s subsequent procedure. Short videos scrolling through the prostate will be recorded and stored securely on trust computers, or encrypted data storage devices. These videos will enable researchers working across the departments of Urology, Radiology, Mathematics and Engineering to investigate novel ways to three-dimensionally map the prostate and target lesions. Success will enable free-hand targeted trans-perineal biopsy without the need for supporting gantries or a biopsy grid placed over the perineum. This will significantly decrease costs of trans-perineal biopsy, reduce the number of puncture sites through the perineal skin – reducing pain and bleeding – and reduce the procedure time.

  • REC name

    East Midlands - Leicester South Research Ethics Committee

  • REC reference

    17/EM/0387

  • Date of REC Opinion

    9 Oct 2017

  • REC opinion

    Favourable Opinion