Cantharidin-induced & Suction-Induced Blister Model Method Development
Research type
Research Study
Full title
Development and Optimisation of Methodology Used to Collect and Analyse Blister Fluid from Cantharidin-Induced Blister Model and Suction-Induced Blister Model
IRAS ID
262200
Contact name
Robert Greenhalgh
Contact email
Sponsor organisation
MAC Clinical Research
Duration of Study in the UK
0 years, 1 months, 1 days
Research summary
The purpose of this study is to test two different clinical techniques of inducing a blister. These techniques are called the cantharidin-induced blister model and the suction-induced blister model.
The cantharidin blister model involves the application of a substance called cantharidin (which is sometimes used as a treatment for verrucae) to the skin, causing a blister to form. The suction blister model involves a suction pump being applied to the skin which acts as a vacuum and pulls the top layer of the skin away, causing a blister to form.
The blister fluid is then collected and analysed for different markers of inflammation. These techniques are used to test anti-inflammatory drugs to see if they can reduce inflammation in the blisters. It is not expected that either technique will be painful based on previous studies using them. This study will be used to improve the techniques used to collect blister fluid and to test that the analysis works. There will be no investigational drug administered in this study. However, the challenge agent Cantharone (used for treatment of verrucae) is being administered to induce blisters.
REC name
North East - York Research Ethics Committee
REC reference
19/NE/0088
Date of REC Opinion
15 Mar 2019
REC opinion
Favourable Opinion