Cantharidin-induced & Suction-Induced Blister Model Method Development

  • Research type

    Research Study

  • Full title

    Development and Optimisation of Methodology Used to Collect and Analyse Blister Fluid from Cantharidin-Induced Blister Model and Suction-Induced Blister Model

  • IRAS ID

    262200

  • Contact name

    Robert Greenhalgh

  • Contact email

    robgreenhalgh@macplc.com

  • Sponsor organisation

    MAC Clinical Research

  • Duration of Study in the UK

    0 years, 1 months, 1 days

  • Research summary

    The purpose of this study is to test two different clinical techniques of inducing a blister. These techniques are called the cantharidin-induced blister model and the suction-induced blister model.

    The cantharidin blister model involves the application of a substance called cantharidin (which is sometimes used as a treatment for verrucae) to the skin, causing a blister to form. The suction blister model involves a suction pump being applied to the skin which acts as a vacuum and pulls the top layer of the skin away, causing a blister to form.

    The blister fluid is then collected and analysed for different markers of inflammation. These techniques are used to test anti-inflammatory drugs to see if they can reduce inflammation in the blisters. It is not expected that either technique will be painful based on previous studies using them. This study will be used to improve the techniques used to collect blister fluid and to test that the analysis works. There will be no investigational drug administered in this study. However, the challenge agent Cantharone (used for treatment of verrucae) is being administered to induce blisters.

  • REC name

    North East - York Research Ethics Committee

  • REC reference

    19/NE/0088

  • Date of REC Opinion

    15 Mar 2019

  • REC opinion

    Favourable Opinion