CANFit: home-based exercise programme for patients with cancer
Research type
Research Study
Full title
A phase II, randomised feasibility basket trial of a personalised, multicomponent, home-based exercise programme on disease-free survival among early-stage high-risk recurring cancers in Yorkshire
IRAS ID
327663
Contact name
Cynthia Forbes
Contact email
Sponsor organisation
University of Hull
Duration of Study in the UK
3 years, 2 months, 20 days
Research summary
More people in Yorkshire are diagnosed with lung, breast, and bowel cancer than most of the UK, with some specific cancers at higher risk of returning after treatment. There is some evidence that suggests regular exercise after cancer treatments can help increase the chances of surviving breast and bowel cancers by almost 40%.
However, this evidence is not strong because it mainly comes from observational studies, and there is not enough information in lung cancer to say if there is any survival benefit. Good quality, long-term clinical trials are needed to better understand if exercise should form part of cancer treatment.
This study will compare a personalised, multicomponent, home-based exercise programme with support, against NHS standard care. People who have finished their primary treatments for early-stage, high-risk lung, breast or bowel cancers, who are at higher risk of their cancer returning, will take part for 2 years. Results from this study will inform the design of a larger scale trial and provide initial evidence of whether more active people have longer, healthier lives without their cancer returning, than those who are less active after cancer treatments.
The intervention group's exercise programme will be tailored to their baseline measurements (including cancer type) and access they have (if any) to outside space or exercise equipment. The intervention will include weekly sessions with a qualified exercise professional via video chat or telephone. The programme will include cardio, strength, and flexibility/balance training. Participants will be offered counselling on other aspects of health that affect physical activity, such as goal setting. Counselling appointment will initially be 3 times per week, progressively tapering to none by 6 months.
We will record feasibility outcomes of site set-up, recruitment, intervention delivery and adherence, and adverse events. Clinical measures of disease-free survival will also be collected, alongside patient-reported quality of life and physical-function measures.
REC name
South East Scotland REC 01
REC reference
23/SS/0060
Date of REC Opinion
28 Jun 2023
REC opinion
Further Information Favourable Opinion