Can pre-operative troponin and CRP predict post-operative mortality?
Research type
Research Study
Full title
Can pre-operative troponin and CRP predict post-operative mortality?
IRAS ID
222084
Contact name
Matthew Jackson
Contact email
Sponsor organisation
South Tees NHS Foundation Trust
Duration of Study in the UK
1 years, 2 months, 1 days
Research summary
Studies have shown that small levels of troponin (a blood test used to detect heart muscle damage) detected before patients undergo planned or urgent major surgery on parts of the body other than the heart can predict death following the operation. However, only patients undergoing high risk operations or patients with a high risk of heart problems have been studied and the reasons for this association between troponin detected before an operation and death after the operation are not clear.
A small study performed at our centre to evaluate this finding showed a similar link. We aim to test our previous findings that small levels of troponin before surgery are associated with deaths following surgery in patients undergoing elective (planned) non-cardiac surgery of all types (i.e. an unselected sample) to determine a) how common a raised troponin blood test is before planned major non-cardiac surgery, b) whether markers of inflammation are related to small releases of troponin and c) whether there is an association between troponin, inflammatory markers and death following surgery.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
17/WM/0172
Date of REC Opinion
28 Jun 2017
REC opinion
Further Information Favourable Opinion