CAIR research database v1.0
Research type
Research Database
IRAS ID
334636
Contact name
Daniel Bromage
Contact email
Research summary
CArdiovascular Inflammation Registry (CAIR)
REC name
South West - Central Bristol Research Ethics Committee
REC reference
24/SW/0114
Date of REC Opinion
15 Nov 2024
REC opinion
Further Information Favourable Opinion
Data collection arrangements
Potential participants will be identified by participating centres. At King’s College Hospital and other King’s College London partner sites, patients will be identified through routine clinical practice and by using an open-source retrieval system for unstructured clinical data (CogStack). Other institutions will identify patients according to national regulations and local practices. This will be carried out by the research team.
Personal data from King’s College Hospital will be stored on manual files in a locked, dedicated research office, and on NHS computers. Non-King’s Health Partner sites (including those outside the UK) will store linkage files for their own patients in a GCP-compliant manner and in accordance with local policies. Data will be stored on a research database (REDCap) hosted by King’s College London. Each participating centre will have linkage codes for their own patients only. Therefore, exported data will not be identifiable to other centres.
Specific variables to be stored are given in the Data Collection Template.
Research programme
Following cardiovascular injury, inflammation is vital to activate reparative mechanisms. However, there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis, ventricular remodelling, and heart failure (HF). Several cardiovascular conditions are characterised by inflammation, including myocarditis, MI, and heart failure. Therefore, this database will support research into a large community of patients with cardiovascular disease. In addition, the database will support researchers in the fields of cardiology, inflammation and immunity and computational science. We also anticipate benefits for the wider scientifc community, specifically those studying rare diseases as we hope our approach will provide an example of successful collaborative working.
Research database title
CArdiovascular Inflammation Registry (CAIR)
Establishment organisation
King's College London
Establishment organisation address
Hodgkin Building, Guy's Campus
SE1 1UL