Caffeine and coronary blood flow
Research type
Research Study
Full title
Effect of Caffeine on Adenosine-Mediated Hyperaemia during Invasive Coronary Physiology Measurements in Patients with Stable Coronary Artery Disease
IRAS ID
197355
Contact name
John P Greenwood
Contact email
Sponsor organisation
Leeds Teaching Hospital NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Adenosine is a naturally occurring substance, present in the human body, and plays a role in the regulation of blood flow. It is used as a medication in invasive and non-invasive diagnostic tests for coronary heart disease world-wide. In that setting adenosine, infused into a vein, leads to maximal blood flow to the heart muscle (simulating exercise). Caffeine competes with adenosine therefore reducing its effect. Previous limited studies have suggested that consumption of caffeine (tea, coffee) prior to these investigations for heart disease may potentially lead to unreliable results. Our study will document whether consumption of caffeine does indeed affect the test results, and if by increasing the dose of adenosine during the test, the effect of caffeine can be overcome. For the study, to ensure that we deliver a consistent dose, the caffeine will be given to the participant as an infusion. We will measure blood flow in the coronary arteries during a clinically indicated X-Ray angiogram and pressure wire assessment which the patient is undergoing for the investigation of coronary heart disease. Adenosine is always used during a pressure wire assessment. The patient will be given the caffeine for the purpose of the research only. The findings of our proposed research could be important to the thousands of patient each year who undergo adenosine stress tests in the NHS.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
16/YH/0076
Date of REC Opinion
28 Apr 2016
REC opinion
Further Information Favourable Opinion