C-peptide and exercise in T1D
Research type
Research Study
Full title
The role of residual beta-cell function on glycaemic variability before and after exercise in Type 1 diabetes
IRAS ID
201939
Contact name
Daniel J West
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
When people with Type 1 diabetes exercise, some experience hypoglycaemia (low blood sugar [glucose]), while others do not; in some HbA1c (a marker of diabetes control) gets worse while in others it improves. Exercise is known to increase glucose variability leading to more time with high and low levels. It is now known that many people with long-standing type 1 diabetes can produce small amounts of insulin. It is unknown if this is important for limiting blood glucose variability at rest and around exercise. It is also unknown whether this low level of insulin impacts on important health markers such as how well the body can repair its blood vessels and how much inflammation people have. We will examine the relationships between residual insulin production, glucose variability, blood vessel repair, inflammation and hypoglycaemia fear and incidence, at rest and after exercise in people with Type 1 diabetes.
REC name
North East - Tyne & Wear South Research Ethics Committee
REC reference
16/NE/0192
Date of REC Opinion
15 Jul 2016
REC opinion
Further Information Favourable Opinion