BYPaSS: a Bariatric surgerY ProSpective cohort Study. Version 1.0.
Research type
Research Study
Full title
BYPaSS: a Bariatric surgerY ProSpective cohort Study
IRAS ID
122479
Contact name
Melanie Davies
Contact email
Sponsor organisation
University of Leicester
Research summary
The prevalence of obesity is increasing in all age groups across the world and traditional measures to reduce this epidemic have failed. Bariatric surgery has proven to be effective in reducing weight and reducing cardiovascular risk factors in morbidly obese individuals.
However there is evidence that not all individuals lose the same proportion of weight after surgery and it is fairly common for individuals to put weight back on over time. Determining lifestyle factors which may influence the amount of initial weight loss and level of sustained weight loss after surgery is required.
We aim to establish a cohort of bariatric patients and produce a detailed characterisation of participants prior to surgery. We also aim to identify lifestyle, psychological and biochemical factors which predict successful sustained weight loss at 4 years post-surgery, measured as percentage excess weight loss (%EWL), examined as a continuous and categorical variable. Participants will be followed up for a minimum of four years. Finally we aim To identify lifestyle, psychological and biochemical factors which predict successful changes in BMI, waist circumference, glycaemic measures (HbA1c, fasting and 2 hour glucose), and in participants cardiovascular profile (TG, TC, HDL, LDL, kidney function and microalbuminuria).All individuals on the NHS waiting list for bariatric surgery at the Leicester Royal Infirmary and those on the waiting list for private surgery at Spires Leicester Hospital will be invited to enrol on the study. Recruitment will take place over 2 years.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
13/EM/0211
Date of REC Opinion
17 Jun 2013
REC opinion
Favourable Opinion