BUMP- Blood pressure and metabolic control in pregnancy
Research type
Research Study
Full title
Pilot multiparametric MR study of cardiac assessments in pregnancies complicated by pre-eclampsia or gestational diabetes
IRAS ID
263316
Contact name
Eylem Levelt
Contact email
Sponsor organisation
University of Leeds
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
During pregnancy, heart and circulatory system is extensively modified. Preeclampsia(PE) and gestational diabetes(GDM) are the common pregnancy complications. PE is a syndrome associated with onset of hypertension and protein in urine. It is a leading cause of maternal and perinatal deaths. GDM is defined as glucose intolerance with onset or first recognition during pregnancy. Women with a history of PE and GDM compared to uncomplicated pregnancies are at increased risk for heart and circulatory disease later in life, which led to appreciation of PE and GDM as novel gender specific risk markers. Women with PE have a 3.7 times higher risk of later hypertension, 2.2 times increased risk of coronary heart disease, and 1.8 times higher risk of stroke. Women with a history of GDM had a 60% greater risk of developing heart and circulatoryr disease during follow up. The precise etiology of PE and GDM remains unclear. It is vital to understand the causes of PE and GD, to have better strategies to prevent heart and circulatory diseases in patients with PE and GDM history.
Altered energy metabolism in the heart may play a central role in the development of heart disease. Magnetic Resonance spectroscopy (MRS) allows us to better understand metabolism in heart disease, without the need for contrast or exposure to radiation. Cardiovascular MR (CMR) is a non-invasive imaging technique capable of assessing function, oedema/inflammation and scarring of the heart. When combined with MRS, CMR imaging enables better understanding of the mechanisms of heart disease. The main aim of this study is to better understand pathophysiology of these common pregnancy complications by utilising these MR techniques.REC name
North East - York Research Ethics Committee
REC reference
20/NE/0117
Date of REC Opinion
26 May 2020
REC opinion
Further Information Favourable Opinion