Buckfood study
Research type
Research Study
Full title
Assessing the effects of a buckwheat beverage on postprandial glucose metabolism on healthy and T2D individuals
IRAS ID
253197
Contact name
Madalina Neacsu
Contact email
Sponsor organisation
University of Aberdeen&NHS Grampian
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Research Summary
Buckwheat is a unique crop because is naturally rich in compounds that have shown beneficial effects on glucose metabolism.
A constant high glucose level in blood after meal consumption is an independent risk factor for cardiovascular complications and death. In order to prevent Type 2 Diabetes Mellitus (T2D) and/or its complications it is important to have a strict control of the blood glucose levels after a meal. There are known therapies for the control of the high glucose blood levels such as agents that act on intestinal digestion of carbohydrates and therapeutic agents that mimic the insulin response after a meal. The combination of these type of agents was commonly prescribed in the treatment of T2D.
The aim of the study is to assess the effect of a buckwheat beverage on postprandial glucose metabolism in healthy individuals and those with T2D controlled by medication and diet.Summary of Results
The efficacy of a specialized buckwheat-based food (drink) to modulate postprandial (after meal) glucose metabolism was tested in healthy volunteers and people with type 2 diabetes (T2D). For this study, three volunteer groups (male and females 18+ years old) were recruited: 1.Healthy volunteers (volunteers which are not suffering from T2D and comply with the study inclusion criteria); 2.Individuals with T2D controlled by medication (metformin) and 3.Individuals with T2D controlled by diet and lifestyle only. Primary study objective was to assess the blood glucose levels. Secondary objective is to assess the blood insulin levels.
Main study findings:
-The specialized buckwheat-based food (drink) significantly decreases the postprandial glucose in T2D on metformin and in T2D controlled by diet only.
- The specialized buckwheat-based food (drink) significantly increase the postprandial insulin secretion in T2D on metformin and in T2D controlled by diet only. The results suggest that the postprandial glucose reduction is via to Insulin stimulation.
-The analysis of urine samples revealed that was a significant increase in glucose excreted following the buckwheat food and glucose vs glucose alone in healthy volunteers and in metformin volunteers group at 150 and 300 minutes after the consumption of the intervention products.
-The analysis of plasma samples revealed that was a significant increase in postprandial concentrations of myo- and d-chiro- inositol following the buckwheat food (and glucose) consumption when compared with glucose alone. Furthermore, postprandial plasma folate concentrations following the Buckwheat food consumption showed an increase when compared with baseline and with glucose alone intervention.REC name
North of Scotland Research Ethics Committee 1
REC reference
18/NS/0132
Date of REC Opinion
3 Dec 2018
REC opinion
Favourable Opinion