BRRIDE 2 Breast Risk Reduction Intermittent Diet Evaluation
Research type
Research Study
Full title
A randomised controlled trial of the effect of Intermittent Energy Restriction (IER) versus Daily Energy Restriction (DER) on body fat stores and blood markers of cancer risk.
IRAS ID
142199
Contact name
Michelle Harvie
Contact email
Sponsor organisation
University Hospital South Manchester
Clinicaltrials.gov Identifier
18052, UKCRN
Duration of Study in the UK
0 years, 7 months, 30 days
Research summary
Obesity increases the risk of developing breast and other cancers. Studies have shown that weight loss can reduce cancer risk but the ideal diet for weight loss is unknown. An ideal diet would be easy to adhere to and preferentially reduce fat stored in the liver and around organs in the abdomen and hence specifically reduce insulin resistance and levels of other circulating hormones and inflammatory blood marker which promote breast cancer. At the same time, an ideal diet would preserve muscle mass and metabolic rate.
Intermittent dieting is an increasingly popular method of dieting (2 day diet book, Harvie & Howell), Fast diet (Mosely & Spencer) which involves short spells of low calorie dieting and spells of normal intake. We have shown that intermittent dieting leads to a greater reduction in insulin resistance than standard daily dieting. We hypothesise that an intermittent diet will lead to a greater reduction in fat within the liver compared to a daily low calorie diet.
We propose to perform a randomised controlled trial comparing an intermittent vs a daily diet in 26 obese women at increased risk of breast cancer. We will compare the effect of these diets on the amount of fat within the liver, pancreas and around organs in the abdomen using magnetic resonance imaging. In addition we will compare the effects of the two diets on insulin resistance, other breast cancer blood markers, muscle mass and metabolic rate. This study will define the effects of intermittent compared to standard dieting on metabolism (such as lower insulin and cholesterol) and the potential effects on reducing breast cancer risk.REC name
South Central - Oxford B Research Ethics Committee
REC reference
14/SC/1097
Date of REC Opinion
14 Jul 2014
REC opinion
Favourable Opinion