Bronchial Alveolar Lavage vs Endotracheal secretions on PICU

  • Research type

    Research Study

  • Full title

    Bronchial Alveolar Lavage vs Endotracheal secretions for diagnosing respiratory tract infections in children on the Paediatric Intensive Care Unit

  • IRAS ID

    268794

  • Contact name

    Michael J Griksaitis

  • Contact email

    Michael.Griksaitis@uhs.nhs.uk

  • Sponsor organisation

    R&D Department

  • Duration of Study in the UK

    0 years, 4 months, 31 days

  • Research summary

    To diagnose any respiratory infection the cause of the problem must be found. This is important as it allows correct choice of antibiotic therapies and to minimise the risk of antibiotic resistance. To gather this information, samples must be gathered and tested either by invasive techniques such as Bronchial Alveolar Lavage (BAL) or by slightly safer, less-invasive sampling of endotracheal (ET) secretions. BAL is currently the sampling method in Southampton’s intensive children’s ward.

    However, there is no evidence to say that one method is better than the other at collecting a sample that provides a true result. This project aims to conclude whether BAL is more accurate at identifying the causes of pneumonia compared to ET secretion sampling. Secondary outcomes will be to identify any adverse events that occur during the sampling process.

    This research will determine which diagnostic method is more accurate and impact all children’s intensive care units in the UK. All microbiological findings, diagnoses, adverse effects and treatment for any child taking part in the study will be noted down to assess the clinical management and help inform any conclusions of this research.

  • REC name

    South Central - Hampshire B Research Ethics Committee

  • REC reference

    19/SC/0429

  • Date of REC Opinion

    20 Sep 2019

  • REC opinion

    Further Information Favourable Opinion