Bronch-EX
Research type
Research Study
Full title
Early Detection of Pulmonary Exacerbations in non-CF Bronchiectasis
IRAS ID
323297
Contact name
Andres Floto
Contact email
Sponsor organisation
Royal Papworth NHS Foundation Trust
Duration of Study in the UK
2 years, 7 months, 30 days
Research summary
Bronchiectasis is a condition where the lungs are permanently widened and damaged. Excess mucus and persistent bacteria lead to frequent infections and problems with breathing such as cough and sputum production.
In addition, for many patients the daily symptoms of the disease are accompanied by unpredictable worsening of symptoms which are more than normal day to day variation. These episodes are known as exacerbations and can have a big impact on patients' daily lives and their life expectancy.
Exacerbations are of critical importance in bronchiectasis and the main goal of treatment is to reduce exacerbation frequency.
The aim of this study is to determine if home monitoring data and artificial intelligence (AI) can be used to detect pulmonary exacerbations before symptoms become clinically apparent.
Secondary aims of this study include
a) to assess the acceptability of home monitoring in patients with bronchiectasis
b) to better understand the development of pulmonary exacerbations through the
collection of medical history and daily sputum collection.
c) to assess adherence to inhaled therapies in those participants who use a Pari
eFlow rapid nebuliser with Pari Connect system for inhaled medications.If this research shows it is possible to detect exacerbations before they become clinically apparent and / or improves understanding of the pathogenesis (process where infection leads to disease) of exacerbations, future research studies will evaluate interventions designed to curtail the development of exacerbations and the subsequent impact on health-related quality of life and bronchiectasis disease progression.
REC name
West of Scotland REC 5
REC reference
23/WS/0128
Date of REC Opinion
27 Sep 2023
REC opinion
Further Information Favourable Opinion