Bristol Pilot RCT of Zoledronic Acid in Malignant Pleural Effusions

• Research type

  Research Study

• Full title

  Bristol Randomised Controlled Trial of Zoledronic acid in Malignant Pleural Effusions (pilot study).

• Sponsor organisation

  North Bristol NHS Trust

• Eudract number

  2009-009134-32

• ISRCTN Number

  Unknown

• Research summary

  Cancer of many types commonly spreads to the lining of the lung causing flud collection (pleural effusion) which is associated with breathlessness and has a negative impact on the quality of life of cancer patients. Simply draining thflud away is not a long term solution as it almost always returns and other commonly used treatments have disappointing success rates and safety profiles.This trial will examine whether a promising drug (Zoledronic Acid) that's already used successfully to protect the bones of cancer patients can reduce the amount oflud produced in the lung lining of cancer patients with the potential to reduce the number of procedures (such as chest drains and needles inserted between the ribs to draiflud) that patients require in the future and improve breathlessness and quality of life. This is an initial pilot study.

• REC name

  South West - Cornwall & Plymouth Research Ethics Committee

• REC reference

  09/H0206/12

• Date of REC Opinion

  18 May 2009

• REC opinion

  Further Information Favourable Opinion