Brighton ARC Study
Research type
Research Study
Full title
Augmented Renal Clearance: a prospective cohort study in emergency admissions to intensive care.
IRAS ID
319953
Contact name
Barbara Philips
Contact email
Sponsor organisation
University Hospitals Sussex NHS Foundation Trust
Duration of Study in the UK
0 years, 12 months, 0 days
Research summary
This observational cohort study aims to look at a broad cohort of general intensive care patients, to gain an understanding of how often we should be expecting to see augmented renal clearance (ARC). This study will recruit patients from the adult Intensive Care Unit (ICU) in the Royal Sussex County Hospital, Brighton. Recruitment will not be restricted by age or reason for admission. To ensure data collection is manageable, patients will be recruited weekly, recruiting those admitted to ICU over the weekend. The exposure in this prospective cohort study is therefore ICU admission, with the outcome as ARC, defined as creatinine clearance >130ml/min/1.73m^2.
Urinary and serum creatinine will be collected from indwelling lines, for up to 5 days from recruitment. The urinary creatinine levels will be used to measure creatinine clearance. Serum creatinine levels are used in 3 different equations to calculate estimated creatinine clearance: Cockcroft-Gault (CG), the Modification of Diet in Renal Disease 7 (MDRD 7), 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi). The estimated and measured creatinine clearance will be compared to assess the accuracy of these equations.
A recent publication produced an ARC prediction tool, giving the probability for a particular patient to develop ARC in the next 24 hours. The research team tested this on patients in Belgium, but it is unknown if this has external validity with a UK cohort, and therefore, if it has use in a UK-based hospital. An online version of this tool is available for research purposes and will be used to investigate the accuracy and precision of the tool when compared to confirmed incidence of ARC in this cohort of patients.
REC name
Wales REC 1
REC reference
24/WA/0080
Date of REC Opinion
19 Jun 2024
REC opinion
Further Information Favourable Opinion