Brain Pulse - Multicentre Study V.1
Research type
Research Study
Full title
Brain tissue pulsations in the presence of brain injury: a multicentre confidence in concept study
IRAS ID
262177
Contact name
Emma Chung
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
This study uses a Doppler ultrasound technique, called Brain Tissue Velocimetry (Brain TV), to investigate brain tissue motion over the cardiac cycle. Brain motion is highly sensitive to heart and brain biomechanics. Preliminary Brain TV measurements from a small number of patients suggest that brain biomechanics may be disturbed in the presence of injury.
The overall aim of this study is to explore the clinical potential of using Brain TV to identify and monitor patients with a range of brain conditions. Specifically, we wish to establish if brain biomechanics are disturbed in the presence of moderate-severe brain pathology to inform further basic science development of the transcranial tissue Doppler (TCTD) technique. This multicentre study involves two NHS Trusts (University Hospitals of Leicester and Nottingham University Hospitals), which will provide access to patients with a wide range of brain conditions.
Data from these patients will help to identify potential clinical applications of Brain TV.
REC name
Wales REC 7
REC reference
21/WA/0374
Date of REC Opinion
9 Dec 2021
REC opinion
Further Information Favourable Opinion