Bp response Assessment BY Pregnancy ANtihypertensive Drug treAtment

• Research type

  Research Study

• Full title

  BABY PANDA: Bp response Assessment BY Pregnancy ANtihypertensive Drug treAtment

• IRAS ID

  307769

• Contact name

  Lucy Chappell

• Contact email

  lucy.chappell@kcl.ac.uk

• Sponsor organisation

  University of Birmingham

• Duration of Study in the UK

  2 years, 2 months, 31 days

• Research summary

  What is the aim of the study?
  To compare how well blood pressure medicines used to treat high blood pressure in pregnancy work over a short time frame.

  Why is this study important?
  One in ten women have high blood pressure in pregnancy. Without treatment, this can cause damage to a woman’s heart, kidneys and brain, and cause harm to her baby. We know that controlling high blood pressure in pregnancy with medicines is important to protect the health of the woman and her baby. There haven’t been enough studies to know which is the best blood pressure medicine to use in pregnancy. Previous studies have shown that the medicines commonly used do not work well in all women.

  We are currently recruiting to the Giant PANDA trial comparing two main blood pressure medicines, called labetalol and nifedipine to find out which one works best to treat high blood pressure, and to check if there are any effects on the baby. We want to see if there are differences in how well how these two medicines control blood pressure over a short time frame (12-24 hours), and to see if this helps us understand how these medicines work. We will also look at whether women’s ethnic background and kidney markers in her blood are related to how well blood pressure is controlled by these medicines. This may help us better understand why some blood pressure medicines do not work well in some pregnant women.

  We also want to see if monitoring blood pressure over 12-24 hours can identify which women will go on to have well-controlled blood pressure throughout their pregnancy. If we can identify which women are unlikely to have good blood pressure control on a particular medicine early, this would allow early switching of their medicine to one that may work better.

• REC name

  Wales REC 6

• REC reference

  22/WA/0047

• Date of REC Opinion

  18 Feb 2022

• REC opinion

  Favourable Opinion