BONES – BOne/renal axis and renal hypertrophy in donor NEphrectomies
Research type
Research Study
Full title
Effect of Donor Nephrectomy on Renal/Bone Axis and Renal Compensatory Hypertrophy in living kidney donors
IRAS ID
156699
Contact name
Sandip Mitra
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
5 years, 0 months, 31 days
Research summary
Chronic kidney disease (CKD) causes weak bones and stiffened blood vessels, linked to shorter life-span and more heart disease. These changes are poorly understood, particularly in early kidney disease. We are hence limited in providing targeted treatments. It is difficult to study people with early kidney disease because they are either unaware of the kidney problem and do not seek medical attention, or have other problems including diabetes which interferes with the investigations. However, living kidney donors are known to be in good health having undergone extensive investigations prior to being allowed to donate a kidney and lose 50% of their kidney function suddenly in a planned procedure. Kidney removal produces transient moderate kidney impairment (CKD stage 3) and therefore an opportunity to study early changes and adaptations in the skeleton and the effect on body content of calcium and phosphate. This may provide the first step to understanding the more advanced changes in late kidney disease which lead to reduced length and quality of life. CMFT is uniquely suited to do this study since it undertakes over 100 live-donor kidney transplants annually - more than any other UK renal centre. Patients are in hospital for 5 days after the operation. The analysis of data will determine the timing and the sequence of changes in bone-mineral metabolism at the start of CKD. In a subgroup of participants we will measure how the volume and structure of the remaining kidneys with functional magnetic resonance imaging (fMRI) to see how the kidneys adapt to the new physiological environment.
REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
14/YH/1157
Date of REC Opinion
5 Sep 2014
REC opinion
Further Information Favourable Opinion