Bone Pain in Multiple Myeloma- a Translational Study
Research type
Research Study
Full title
Bone Pain in Multiple Myeloma- a Translational Study
IRAS ID
268616
Contact name
Andrew Chantry
Contact email
Sponsor organisation
Sheffield Teaching Hospital NHS FT
Clinicaltrials.gov Identifier
n/a, n/a
Duration of Study in the UK
1 years, 11 months, 16 days
Research summary
What are the mechanisms underlying bone pain in multiple myeloma?
Pain is a serious symptom of multiple myeloma that affects approximately 70% of the patients, impairing their quality of life. However, there is a lack of clinical studies addressing the underlying mechanisms of myeloma-induced bone pain.
The aim of this clinical study is to characterize the self-assessed experience of pain in myeloma patients, and how it correlates to changes in the neuronal fibres innervating their bones, as well as to blood biomarkers. Understanding these changes will aid in the identification of novel targets to develop analgesic treatments with higher efficacy and fewer side effects.
For that purpose, patients with suspected multiple myeloma undergoing diagnostic procedures at Sheffield Teaching Hospital will be invited to participate.
Patients will be asked to fill in a series of questionnaires addressing their personal experience of pain and its interference in their quality of life, and blood samples will be taken. Bone biopsies obtained for diagnostic purposes will be thereafter examined to identify changes in the neuronal fibres.
Patients who receive a positive multiple myeloma diagnosis will be invited to participate in a follow-up, which will take place 8 months later, upon completion of first-line treatment for their disease. In the follow up, the pain experience will again be assessed with standardized questionnaires and blood samples will be taken. Bone biopsies are routinely taken at this point to evaluate treatment efficacy; thereafter, these biopsies will be evaluated to identify the effect of treatment of the neuronal profiles innervating the bones.
This follow-up will provide information on the effectiveness of first-line multiple myeloma treatment on the myeloma-induced bone pain. This study is part of a collaborative project between Sheffield Teaching Hospital and University of Copenhagen, and it is funded by IMK Fonden, a non-commercial Danish foundation.REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
19/YH/0319
Date of REC Opinion
16 Sep 2019
REC opinion
Favourable Opinion