Bone microarchitecture in Acute Lymphoblastic Leukaemia
Research type
Research Study
Full title
A pilot study of MRI bone microarchitecture in survivors of childhood onset acute lymphoblastic leukaemia (ALL)
IRAS ID
236161
Contact name
Jarod Wong
Contact email
Sponsor organisation
NHSGreater Glasgow and Clyde
Duration of Study in the UK
2 years, 0 months, 5 days
Research summary
There is increasing evidence that people with acute lymphoblastic leukaemia (ALL) are at increased risk of osteoporosis or weaker bones. The cause for this is not clear. Current methods of assessing bone health such as bone density scans (DXA) do not provide sufficiently detailed information on the inner structure of bones in these people and do not identify those with ALL who are at high risk of fractures.
The purpose of this study is to use novel methods of imaging in the form of 3T-MRI and MRS (magnetic resonance spectroscopy) to assess the bone and muscle health of children and adolescents who are survivors of ALL. We believe that MRI scans represent an excellent way of investigating the detailed structure of bone and novel MRI techniques have previously been used to assess the bone health of children and adults with various chronic diseases.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
18/EE/0232
Date of REC Opinion
23 Aug 2018
REC opinion
Further Information Favourable Opinion