BMP4, BMP7 and BMP receptor expression in ovaries of PCOS patients
Research type
Research Study
Full title
To explore the expression and significance of BMP4, BMP7 and their receptors in ovaries of PCOS patients.
IRAS ID
174386
Contact name
Paul Hardiman
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
15/0288, Registered R&D project ID number
Duration of Study in the UK
0 years, 2 months, 27 days
Research summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders and also one of the main reasons for female infertility. The incidence of this ovulatory disorder is approximately 6-10% among women in reproductive age (Khalaf et al., 2013). Currently, the pathogenesis of PCOS affects the maturation of follicular development remains unclear. Follicular development depends on the co-regulation of various growth factors. Bone morphogenetic protein 4 (BMP4) and BMP7 are key members of the transforming growth factor β (TGFβ) superfamily. They belong to the oocyte secreted factors and play an important role in folliculogenesis, ovulation, the granule cells development and apoptosis. In order to reveal the reason why PCOS affects follicular development, this research will use immunohistochemistry, in situ hybridization to compare the difference of BMP4, BMP7 expression and their receptors BMPR-IA, BMPR-IB, BMPR-II and ALK2 expression in archived ovarian tissue (from subjects with PCOS and controls who do not have this condition). The expected research period is around nine months.
REC name
South Central - Berkshire Research Ethics Committee
REC reference
15/SC/0360
Date of REC Opinion
2 Jun 2015
REC opinion
Favourable Opinion