Blood test for detection and monitoring of early stage osteoarthritis
Research type
Research Study
Full title
The development and validation of a blood test for detection and monitoring of early-stage osteoarthritis
IRAS ID
192081
Contact name
Naila Rabbani
Contact email
Sponsor organisation
University of Warwick
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
In our previous studies we accurately determined the concentration of protein damage markers in patients who have varying degrees of osteoarthritis and rheumatoid arthritis. The results of our study showed that certain biomarkers are elevated in patients who are in the early stages of osteoarthritis and rheumatoid arthritis. Certain combinations of the markers have demonstrated diagnostic sensitivity when evaluated by machine learning algorithms.
In osteoarthritis, it is well known that the degeneration in the joint precedes the onset of symptoms by many years and at present there are no biochemical markers in use for diagnosing osteoarthritis. In this new study we wish to acquire samples from patients with early stage hip OA and a control group to carry out a blinded analysis to determine the sensitivity of our technique and validate our algorithm for detection of early OA in hips. We also hope to correlate our markers with clinical, radiological and arthroscopic findings within the early OA group.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
16/WM/0024
Date of REC Opinion
25 Jan 2016
REC opinion
Unfavourable Opinion