Blood flow dynamics in the surviving adult congenital heart patient
Research type
Research Study
Full title
Blood flow dynamics in the surviving adult congenital heart patient
IRAS ID
240429
Contact name
Asimina Kazakidi
Contact email
Sponsor organisation
University of Strathclyde
Duration of Study in the UK
2 years, 4 months, 30 days
Research summary
Advancements in the medical diagnostic modalities and the success of paediatric surgery have led to a major increase in the adult population with Congenital Heart Disease. These patients frequently require reoperations due to structural abnormalities within the cardiac circuit. Pulmonary valve replacement is the most frequent reoperation executed in repaired patients with Tetralogy of Fallot; however, there is an ongoing debate regarding the optimal timing for this operation. The current indications for pulmonary valve replacement include symptoms and increased Right Ventricle (RV) volume. The aim of this work is to haemodynamically describe pre-operative congenital heart lesions and predict possible post-operative blood flow development. The project is a secondary analysis of existing datasets and will focus on the pulmonary bifurcation, trying to establish a novel metric that clinicians could use to determine the need for pulmonary valve replacement. For the purpose of this research pre- and post- operative MRI and CT images, from the Golden Jubilee Hospital in Glasgow, will be processed. The images will be from consent patients with congenital heart lesions, of age 18 years old and above, that had or are considered for pulmonary valve replacement. The images are part of existing regular clinical screening and no new CT or MRI scans will be conducted to any patient for the purpose of this research. The images are sited as datasets in the NHS Golden Jubilee National Hospital and will be processed only after encrypted and anonymised (all metadata and patient information will be completely removed) by the clinicians at the hospital. 3-D patient specific computational models will be constructed and used to visualise the blood flow in the pulmonary arteries of these group of people. The PhD study will last for 3 years and it is funded by the University of Strathclyde.
REC name
HSC REC B
REC reference
18/NI/0082
Date of REC Opinion
24 May 2018
REC opinion
Further Information Favourable Opinion