Blastocystis' impact on the gut microbiome Version 1
Research type
Research Study
Full title
The pathogenic potential of the protozoan anaerobe Blastocystis and its impact on the gut microbiome
IRAS ID
274985
Contact name
Anastasios Tsaousis
Contact email
Sponsor organisation
University of Kent
Duration of Study in the UK
2 years, 11 months, 16 days
Research summary
Can the presence of the microbe Blastocystis have a disease causing effect in patients with gastrointestinal symptoms.
The microbe Blastocystis resides in the gastrointestinal tract and is extremely prevalent worldwide with approximately 1 billion cases. Many cases are asymptomatic, however evidence exists which suggests that it has a role in causing gastrointestinal symptoms. The prevalence and long term colonisation of Blastocystis have led to it being a public health concern. Many studies have produced evidence suggesting that the presence of this microbe has a significant effect on the surrounding gut microbiome. This could be beneficial or detrimental to gastrointestinal health as there is a strong correlation between the plethora of microbes in the gut and a healthy gut. This study examines the relationship between the presence of Blastocystis and certain parasites in the gut as well as the molecules it produces, both of which may be hugely relevant to its potential disease causing mechanism. The study will be conducted at the University of Kent over a three year period using stool samples collected from subjects over the age of 18 with gastrointestinal symptoms. There will also be stool samples collected from a cohort of healthy volunteers used as controls. The stool samples will be examined for the presence of Blastocystis, various parasites and the molecules these microbes may produce. Steps will be taken to ensure that the anonymity of all participants, both healthy volunteers and NHS patients is protected.
REC name
HSC REC A
REC reference
20/NI/0046
Date of REC Opinion
23 Mar 2020
REC opinion
Further Information Favourable Opinion