Bladder sensation in health and disease
Research type
Research Study
Full title
Bladder sensation in health and disease
IRAS ID
187859
Contact name
Douglas Tincello
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
1 years, 8 months, 0 days
Research summary
There are gaps in our knowledge about people’s conscious bladder control and whether these differ across age and gender. Bladder symptoms such as urgency, frequency and incontinence are common and can have a negative impact on quality of life. They carry a social stigma that can lead to isolation, depression and anxiety.
The initial stage of the study is to determine the required volume of water to be drunk to achieve constant urine production in men and women. After this we will be able to explore the relationship of urinary bladder volume and the perceived sensations. Recently, a bladder-sensation data-logging tool has been developed that requires drinking a specific amount of water every 15 minutes to achieve rapid and non-invasive bladder filling. Participants are then required to express their bladder fullness.
We know that there is a difference between different age groups and between common disorders of bladder function and we would like to investigate this further.
For the initial stage we will be recruiting healthy volunteers through advertisements. For the subsequent stages (to find a pattern of bladder sensation between patients with common disorders of urine function) we will be identifying patients from Urogynaecology and urology clinics. Healthy volunteers and patients will be consented prior to the test.
Participants will attend 2 sessions 7 to 14 days apart. The test will take place at the clinical research unit at the Leicester Royal Infirmary.REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
15/WM/0399
Date of REC Opinion
2 Dec 2015
REC opinion
Further Information Favourable Opinion