Bladder function following surgical excision of endometriosis v1.0
Research type
Research Study
Full title
Pre‐ and post‐operative bladder function in women undergoing excision of endometriosis
IRAS ID
203207
Contact name
Vasileios Minas
Contact email
Sponsor organisation
Wirral University Teaching Hospital
Duration of Study in the UK
2 years, 0 months, 30 days
Research summary
Endometriosis is defined by the presence of endometrial tissue outside the uterine cavity. It affects approximately 1 in 10 women of childbearing age. The symptoms range from none or mild, to severe pelvic pains which disrupt quality of life. Urinary dysfunction (UD) occurs in up to 29.2 % of cases following surgery for deeply infiltrating endometriosis (DIE) and is thought to result from damage to pelvic splachnic nerves. Clinical experience suggests that the majority of these cases improve over time, but few studies have examined the long‐term outcome. In addition, only some of these studies have evaluated the presence of UD before surgery and correlated this with the outcomes following surgery.
We will evaluate UD prior to and following surgery for DIE. We will investigate the incidence of de novo development of post‐operative UD and its long‐term outcome as well as the presence of pre‐operative UD as a risk factor for exacerbation of UD after surgery. Data from cases with DIE will be correlated with data from women undergoing diagnostic laparoscopy. We anticipate that this study will produce data on the long‐term outcome of UD in women undergoing surgical treatment for DIE and will examine whether post‐operative UD can be predicted by pre‐operative
assessment. These results will provide valuable information for both surgeon and patients during counseling consultations and may reveal a need for pre‐operative assessment and optimization of urinary function, for example by physiotherapy.This will be a prospective study in a setting of a tertiary referral center for the surgical management of complex endometriosis. Patients undergoing elective surgery for endometriosis and diagnostic laparoscopy will be invited to fill in the bladder section of the validated Queensland pelvic floor questionnaire within 6 months prior to surgery and at 1 month and 6 to 12 months following surgery.
REC name
South Central - Oxford B Research Ethics Committee
REC reference
16/SC/0250
Date of REC Opinion
29 Apr 2016
REC opinion
Favourable Opinion