Birdshot Dataset Study (BIRD-SET)

• Research type

  Research Study

• Full title

  Creating a Genotype and Phenotype Dataset in Birdshot Chorioretinopathy

• IRAS ID

  333329

• Contact name

  Colin Chu

• Contact email

  colin.chu@ucl.ac.uk

• Sponsor organisation

  Moorfields Eye Hospital

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  This observational study will generate a large and unique set of data to significantly advance our understanding of Birdshot Chorioretinopathy (BCR), which is an autoimmune eye disease. It will bring together different approaches by combining clinical, genetic and imaging data with blood, functional and immune system analysis. Up to 180 participants will be recruited, 150 from Moorfields Eye Hospital (MEH) and 30 from University Hospital Birmingham (UHB). This study hopes to make new discoveries into Birdshot Chorioretinopathy that could identify new diagnostics, treatments and monitoring approaches.
  The study does not involve taking any study medication, or require or result in any changes to the participants standard of care. The participant will be expected to be consented, samples taken and imaging offered on a single visit, that may or may not be on the same day as their normal clinic appointment.
  All samples, information and data will be anonymised, so no personally identifiable information will be shared outside the NHS.
  This study is defined by 3 pathways and the participant will be informed which one they are being entered into.
  Pathway 1 will involve all participants where clinical and retinal imaging data including confirmation of basic information about medical history will be collated. A single saliva sample will be collected to extract DNA. Participants will be invited to enrol onto two linked external studies run through the NHS: Birdshot-ABC Study where permission to collect future and historical clinical and retinal imaging data will be requested. NIHR Bioresource Rare Disease Study where a normal blood test’s worth of blood (approximately 14ml) will be requested to be stored (‘biobanked’) for future research.
  Pathway 2 and 3 will involve selected participants only where in addition to Pathway 1 activities, additional blood testing and non-invasive retinal imaging by Optoretinography (ORG) will be included

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  23/PR/1257

• Date of REC Opinion

  22 Nov 2023

• REC opinion

  Further Information Favourable Opinion