BIOPEX Version 2
Research type
Research Study
Full title
Biological mesh closure of the pelvic floor after extralevator abdomino perineal resection for rectal cancer
IRAS ID
132073
Contact name
Baljit Singh
Contact email
Sponsor organisation
University Hospitals Leicester
Clinicaltrials.gov Identifier
Research summary
Patients with rectal cancer may require surgery in the form of an eLAPE (extra levator abdominoperineal excision) procedure. This type of surgery results in permanently removing the anus and having a permanent bag (stoma). However as part of the surgical procedure a large part of tissue is removed from the back passage, which results in a significant defect. There is no consensus on the method for closing this defect. The options include using a biological mesh, commonly made from pig tissue, or using the existing tissue to close the defect (primary closure). This study aims to answer which of these two techniques results in fewer breakdown of the perineal wound.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
14/EM/0048
Date of REC Opinion
21 Feb 2014
REC opinion
Favourable Opinion