Biomarkers of healthy aging and neurodegenerative disease (BIO-AGE) v1
Research type
Research Study
Full title
Diagnostic biomarkers of gut microbiome-associated phenotypes predictive of healthy aging and neurodegenerative disease (BIO-AGE)
IRAS ID
303109
Contact name
Jay Amin
Contact email
Sponsor organisation
University of Southampton
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Different bacteria in the gut have been linked with longevity and healthy ageing. Some gut bacteria can activate the body’s immune system though, which can cause harm if not kept in check. This project will aim to identify genes in older people as well as the parts of the gut bacteria that are associated with healthy ageing and with different brain diseases.
Using the latest technology, we will apply cutting edge measurement of gut bacteria from older people with Alzheimer’s disease, Parkinson’s disease and Dementia with Lewy bodies, and people without these diseases. In this project, we are working with a commercial partner called TopMD to combine the information from the gut bacteria with genetic information we will analyse from blood, skin and saliva samples. We aim to develop the first ever combined test of gut bacteria and genes that will be used to help diagnose brain diseases.REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
21/WM/0252
Date of REC Opinion
20 Oct 2021
REC opinion
Favourable Opinion