Biomarkers of Delirium after Neck of Femur Fracture (BDA-NOF)

• Research type

  Research Study

• Full title

  Biomarkers of Delirium after Neck of Femur Fracture (BDA-NOF)

• IRAS ID

  192913

• Contact name

  Michael B Fertleman

• Contact email

  m.fertleman@imperial.ac.uk

• Sponsor organisation

  Imperial College NHS Trust

• Duration of Study in the UK

  0 years, 11 months, 31 days

• Research summary

  This is an observational cohort study of persons aged ≥60 with acute fractured neck of femur. Relevant exposures include: demographic, clinical and biomarker (blood, CSF, urine) factors. Primary outcome will be the presence and severity of delirium following surgery, analysis of the samples will permit the identification of biomarkers associated with the development of post operative delirium.

  Our hypothesis is that the clinical state of post-operative delirium is associated with a change in biomarkers in the blood/urine/CSF of patients. This study will allow us to detect these biomarkers, thereby aiding the rationale of future therapeutic trials.
  The aim of this study is to identify biomarkers associated with post-operative delirium in patients undergoing orthopaedic surgery. Routine delirium ascertainment is embedded in our NHS work, through the use of neuropsychometric tests examining cognitive functioning in patients before and following surgery for broken hip.

• REC name

  London - Stanmore Research Ethics Committee

• REC reference

  16/LO/0183

• Date of REC Opinion

  11 Feb 2016

• REC opinion

  Favourable Opinion