Biomarkers for chronic venous insufficiency (CVI): A preliminary study
Research type
Research Study
Full title
A Preliminary Investigation of Biomarkers of Inflammation For The Exploration of The Mechanism of Venous Disease Progression.
IRAS ID
227710
Contact name
Mark S Whiteley
Contact email
Sponsor organisation
The Whiteley Clinic
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Chronic venous insufficiency (CVI) of the lower limb is the venous reflux disease affecting the superficial, deep or perforating veins. When the cause of CVI is restricted to superficial and/or perforating veins, it is known as superficial venous reflux (SVR). This affects the majority of CVI patients, which is treatable by endovenous techniques. SVR in the lower limb can lead to varicose veins which can further result in discomfort, skin changes leading to venous eczema or venous ulcers. \nAt least 50% of the patients with SVR show no obvious varicose veins externally. These patients are usually the ones that can then progress to the complications of SVR. Previous research has shown venous reflux disease leads to inflammatory changes in blood samples taken from the feet when patients stand up and venous reflux occurs. The study is designed to look at blood samples of patients with varying stages of CVI according to clinical classification scores. The aim of the study is to investigate if compositional markers of blood profiles alter according to disease states and is affected by time. \n\nParticipants’ CEAP classification scores are to be noted. Blood samples taken from the arm and near the ankle when lying down and standing. Participants will be asked to stand and blood samples from the arm and ankle will be taken again at different time points Each participant will have 8 blood samples taken. These blood samples will be analysed for differences in the composition of blood in recumbent and standing blood profiles. This will be quantified. The study will last for 6 months.
REC name
London - Hampstead Research Ethics Committee
REC reference
17/LO/0969
Date of REC Opinion
14 Jul 2017
REC opinion
Unfavourable Opinion