Biological Rhythms in Human Skeletal Muscle v1
Research type
Research Study
Full title
Biological Rhythms in Human Skeletal Muscle
IRAS ID
152929
Contact name
James Betts
Contact email
Sponsor organisation
University of Bath
Research summary
The human body regulates regulates itself on a daily basis via a circadian timing system, involving 'clocks' in various tissues. Skeletal muscle is a major site for glucose disposal, so plays a major role in healthy glucose control and can be impaired by poor lifestyle choices related to diet and exercise. It is therefore interesting that no previous study has explored circadian timing systems in this tissue in human participants. We plan to have volunteers rest in our laboratory for a controlled 24-h period (i.e. managed exposure to important cues like light and food), with serial muscle biopsies sampled every 4 hours to reveal the fluctuations in muscle metabolism over a daily cycle.
REC name
South West - Cornwall & Plymouth Research Ethics Committee
REC reference
14/SW/0123
Date of REC Opinion
14 Jul 2014
REC opinion
Further Information Favourable Opinion