Biological mesh outcomes in cCAWR v1.0
Research type
Research Study
Full title
Investigating short- & long-term outcomes with the use of biological mesh in contaminated complex abdominal wall reconstructions: Prospective cohort study
IRAS ID
299026
Contact name
Carolynne Vaizey
Contact email
Sponsor organisation
Imperial College London
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Complex hernias are difficult to manage and repair and may need special techniques and mesh used as part of the operation. Often patients who have a complex abdominal wall hernia may have had many previous operations and might have medical conditions that can affect their healing. These factors can mean that patients are at a higher risk of complications after their operation compared to other patients having open abdominal operations. Previous studies have shown that patients who suffer with specific medical conditions and those who have had many previous abdominal operations appear to be at an increased risk of complications and problems recovering after such operations, and possibly increased risk of recurrence of their hernia. This may have a significant impact on the patient’s quality of life and may indeed require further surgery in the future, which is often a significant undertaking.
There have been studies looking at the use of different types of mesh for these operations and the short-term outcomes associated with each. The use of special mesh called biological mesh in these contexts appears to be associated with fewer post-operative complications and improved healing. However, these mesh are relatively new and data on longer-term outcomes with their use is very limited, with no studies looking at long-term quality of life outcomes for these patients.
We want to review how patients undergoing these operations with the use of biological mesh recover in hospital after their operation, and whether they experience any complications or problems in the short-, medium- and long-term. We would like to see if we can identify any factors that might be related to better patient outcomes. Additionally, we want to increase our understanding on the impact of these operations and the recovery on patient’s quality of life and any possible economic implications.
REC name
HSC REC B
REC reference
22/NI/0054
Date of REC Opinion
31 Mar 2022
REC opinion
Further Information Favourable Opinion