Biological markers of renal involvement in systemic sclerosis (v.1.0)
Research type
Research Study
Full title
Biological markers of renal involvement in systemic sclerosis
IRAS ID
145807
Contact name
Christopher Denton
Contact email
Sponsor organisation
Royal Free London NHS Foundation Trust
Research summary
Systemic sclerosis (SSc) is a disease that affects many different parts of the body, including the skin and internal organs, and it develops differently in each patient. In some patients SSc affects the kidneys. About one in twenty SSc patients will have a life threatening form of kidney disease called scleroderma renal crisis (SRC) but many more will have milder kidney damage caused by SSc. The reasons why some patients with SSc get kidney disease and others don't are not well understood. We plan to look at new protein markers of disease in samples of blood and urine. We will compare these markers between four groups: people with SSc and kidney disease, people with SSc and no kidney disease, people with kidney disease from other causes and healthy volunteers. Observing the difference in the blood and urine between these four groups, together with other information we gather about these people with routine tests in the clinic, will help us to understand more about what causes kidney disease in SSc and how to treat it.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
13/NE/0375
Date of REC Opinion
6 Jan 2014
REC opinion
Favourable Opinion