Biological markers of radiation exposure following fluoroscopy - pilot
Research type
Research Study
Full title
Biological markers of radiation exposure in whole blood sampled from patients undergoing fluoroscopic procedures - a pilot study.
IRAS ID
131732
Contact name
Mark Pearce
Contact email
Research summary
Ultimately, we plan to undertake a large-scale study looking at a range of radiation doses from fluoroscopy and a range of biological endpoints. However, such a study needs pilot work before a full study protocol and funding application can be written, to ensure the best chance of success. Therefore, the objectives of this proposed pilot study are to test the feasibility of assessing a panel of biomarkers (before and after exposure to clinical doses of ionising radiation) as part of a major epidemiological study, in order to further inform the link between direct and late effects of radiation and epidemiological outcomes. This is with the aim of identifying the markers that would be most informative within the framework of a larger scale parallel biological and epidemiological study looking at low dose ionising radiation exposures. In this pilot study, we will take blood samples from 40 patients undergoing interventional cardiology at the Freeman Hospital, Newcastle upon Tyne at selected time points before and after the cardiology procedure takes place. Using these samples, we will measure a range of genetic, epigenetic and blood-based biomarkers and how they change following the radiation exposures received during the cardiology procedure.
REC name
North East - York Research Ethics Committee
REC reference
13/NE/0214
Date of REC Opinion
2 Oct 2013
REC opinion
Further Information Favourable Opinion