Bicarbonate for older Chronic Kidney Disease patients with Acidosis
Research type
Research Study
Full title
Does oral sodium bicarbonate therapy improve function and quality of life in older patients with chronic kidney disease and low-grade acidosis? A multicentre randomized placebo controlled trial
IRAS ID
93363
Contact name
Miles D Witham
Contact email
Sponsor organisation
University of Dundee
Eudract number
2011-005271-16
ISRCTN Number
ISRCTN09486651
Research summary
Older people with advanced chronic kidney disease (CKD) often have high levels of acid in their blood. This acid may cause muscle weakness, tiredness, as well as further problems with blood vessel, kidney and bone health.
Acid in the blood (acidosis) is commonly treated with sodium bicarbonate (a substance used in baking powder). It is not clear whether bicarbonate treatment improves muscle strength, wellbeing, bone, kidney or blood vessel health. Side effects can include ankle swelling and high blood pressure.
This randomised controlled trial will test whether bicarbonate improves muscle strength, physical function, quality of life and kidney function in older CKD patients with high acid levels in the blood, as well as testing how common side effects are, and whether bicarbonate can improve blood vessel and bone health. We will also assess the cost-effectiveness of bicarbonate treatment in this condition. 380 patients will be recruited, with each patient receiving bicarbonate or placebo capsules daily for two years.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
12/ES/0023
Date of REC Opinion
16 Mar 2012
REC opinion
Favourable Opinion