BEST-2
Research type
Research Study
Full title
The Bedside Evaluation of Sensitive Troponin 2 Study
IRAS ID
303373
Contact name
Richard Body
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
ISRCTN Number
ISRCTN48377837
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
When patients are admitted to hospital with suspected heart attacks they must often have blood tests over a number of hours before the diagnosis of a heart attack (acute myocardial infarction) can be excluded. The tests measure cardiac troponin, a marker of heart injury. Over the last decade, high-sensitivity cardiac troponin assays have been widely implemented and, by precisely detecting small concentrations of cardiac troponin, allow much faster diagnosis of heart attacks than was previously possible.
Point of care high-sensitivity cardiac troponin assays, which sensitively measure cardiac troponin levels within minutes at the patient's side, are now available. In this study, we will test the accuracy of new point of care high-sensitivity cardiac troponin assays for the diagnosis of acute myocardial infarction in the Emergency Department (ED).
In this study, we will ask consenting patients presenting to the ED with chest pain or similar symptoms if they would donate blood samples for analysis in this research. We will draw blood on arrival and 1 hour later. The blood will be tested for levels of cardiac troponin using the new point of care assays. We will also collect data about patient's symptoms and past history to see if using established risk scores and decision aids alongside the new troponin assays will improve diagnosis. Patients will undergo standard clinical assessment as part of the routine care and we will check if they have had any further cardiac events over the next 30 days by checking medical records +/- contacting the patient or their general practitioner, and an expert panel will determine whether the final diagnosis was acute myocardial infarction.
The study will enable us to understand whether the new tests can be used in practice, enabling faster diagnosis and more efficient use of NHS resources.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
22/EM/0005
Date of REC Opinion
16 Feb 2022
REC opinion
Further Information Favourable Opinion