Benchmarking Breast Cancer recurrence in NCRAS and Greater Manchester

• Research type

  Research Study

• Full title

  Benchmarking Breast Cancer recurrence prospectively in NCRAS and Greater Manchester to validate a realtime algorithm for recurrence.

• IRAS ID

  275022

• Contact name

  Nigel Bundred

• Contact email

  nigel.bundred@manchester.ac.uk

• Sponsor organisation

  The University of Manchester

• Duration of Study in the UK

  1 years, 6 months, 31 days

• Research summary

  Internationally, local recurrence (LR) rates after breast cancer surgery have fallen to 3% or less currently. The UK national target is a LR rate of less than 2.5% at 5 years.
  One factor that predicts LR is leaving ‘margins’ where cancer cells are found at the edge of the tissue that has been removed. Our hypothesis is that involved margins cause distant recurrence.

  Using data analysed by the National Cancer Registration and Analysis Service (NCRAS) in a pilot study, investigating mortality after breast cancer in 52317 patients with (8325 deaths), surgical margin involvement (definition <1mm: 12,246(23%) involved margins) were associated with increased cancer mortality and lower socioeconomic status.

  We aim to determine margin involvement and its effect on local/distant recurrence and overall survival from cancer in a GM breast cancer audit (3500 patients) and NCRAS data (52317 patients). We aim to collaborate with Public Health England for them to analyse data within HES, IMD and NCRAS datasets to define patient characteristics that may influence survival and other outcomes. We aim to study population-level variability in use of margins and uptake of cancer recurrence according to geography, socio-economic status and provider trust. Data will not have patient identifiers.
  This will help the NHS target risk factors for local and distant recurrence by helping patients understand related risk factors.

  As part of the NHS Long Term Plan, a priority is improving and benchmarking Quality of Cancer Care and treatment which this project will deliver by benchmarking surgical care in England within the timeframe of the grant. Another priority this research will look to tackle is health inequalities, particularly focusing on particular communities and groups of people most affected by smoking, drinking, type 2 diabetes.

• REC name

  London - Bloomsbury Research Ethics Committee

• REC reference

  21/PR/0834

• Date of REC Opinion

  2 Aug 2021

• REC opinion

  Further Information Favourable Opinion