Barts Sex-CAD Database
Research type
Research Study
Full title
Do female sex hormone levels inform inflammatory status and susceptibility in women suffering coronary artery disease?
IRAS ID
316012
Contact name
Krishnaraj Rathod
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
It is now accepted that bias, in its many forms, plays a substantial role in our lack of understanding of coronary artery disease (CAD: blocking (furring up) of the arteries of the heart) initiation and progression in women. Women who suffer a heart attack have double the risk of further heart attacks compared to men, despite conventional treatment that work well in men. Women also experience much greater rates of heart attacks that occur without block of the arteries that feed the heart, than their age-matched male counterparts. It is thought that differences in biology play an important role in these differences with sex hormones and differences in inflammatory status key elements. In this single centre registry study we wish measure sex hormone levels and markers of inflammation in patients attending Barts Heart Centre with CAD in order to better understand the influence of sex on coronary artery disease. We wish to determine menstrual status of female patients with CAD using telephone questionnaires following discharge from hospital. We will add this data to the already established Barts Heart Centre interventional patient database (BartsREVASC Database) for all patients, females included. Our hope is that via this study we might address a neglected area of research, determining whether the addition of sex hormone analysis can influence clinical decision making thereby paving the way for a future clinical trial on this subject.
REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
23/YH/0194
Date of REC Opinion
7 Nov 2023
REC opinion
Further Information Favourable Opinion