Azithromycin in Asthma

• Research type

  Research Study

• Full title

  Predicting Response to Azithromycin Therapy in Asthma

• IRAS ID

  65416

• Contact name

  Dominick Shaw

• Eudract number

  2011-000237-36

• ISRCTN Number

  N/A

• Clinicaltrials.gov Identifier

  N/A

• Research summary

  One type of lung condition; known as Asthma, causes inflammation of the airways, making it difficult to breathe and often leads to shortness of breath. Azithromycin is an antibiotic treatment which recently has been used in the successful treatment of Asthma. However at the moment, we have a limited understanding of why some people with Asthma respond well to Azithromycin and others do not. Researchers wish to look at a variety of biomarkers found in small samples of the airway tissue, in people with Asthma and people without (healthy controls). Samples of airways tissue will be taken by bronchoscopy ?? this is a procedure where a small flexible telescope is inserted down the back of the throat and into the airways. After taking a course of azithromycin tablets once daily for six weeks, repeat samples of airways tissue will be taken to assess the effects. It is hoped that by studying these biomarkers, it will lead to a greater understanding of why some people with Asthma respond well to Azithromycin and others do not, and hopefully find new ways of treating/managing Asthma. Participants will each be involved in the study for up to eight weeks.EudraCT -2011-000237-36

• REC name

  East Midlands - Nottingham 2 Research Ethics Committee

• REC reference

  11/EM/0062

• Date of REC Opinion

  20 May 2011

• REC opinion

  Further Information Favourable Opinion