Automated, quantitative pupil assessment using binocular OCT
Research type
Research Study
Full title
A Prospective Single-Site Non-Interventional Study to Evaluate the Diagnostic Accuracy and Repeatability of Pupil Measurements using a Prototype Binocular Optical Coherence Tomography System.
IRAS ID
214786
Contact name
Pearse Keane
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
UCL Data Protection Registration, Z6364106/2016/10/31
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
A new form of OCT imaging has recently been developed – “binocular” optical coherence tomography (OCT). Binocular OCT addresses many of the short-comings of conventional OCT devices, plus also adds a number of unique capabilities. In particular, binocular OCT removes the need for additional personnel to acquire the images by enabling patients to align the optical axes of the instrument with the optical axes of their own eyes. The system also employs recently developed “swept-source” lasers as its light source, allowing it to see deeper into the eye than conventional OCT systems. Finally, binocular OCT systems allow image capture from both eyes at the same time. This “simultaneous” ocular imaging extends the range of diagnostic testing possible, allowing for features such as pupillometry and ocular motility.
A prototype binocular OCT was assembled at Moorfields Eye Hospital in May 2016 as part of another clinical study (The EASE Study; UCL JRO study number 15/0367). Ethical approval for this study was given by the London Central Research Ethics Committee (REC ref 15/LO/1756).
The Moorfields binocular OCT system is capable of capturing real-time high-speed OCT images through the iris planes of both eyes simultaneously. Pupillometry testing on this device involves presenting a low intensity fixation target to the user on the internal screen within the device. A controlled flash of light is then presented to each eye in turn while the OCT dynamically captures images through the iris planes. By measuring the width of the pupil in rapidly acquired pairs of images, pupil parameters such as maximum and minimum pupil diameter, velocity, and amplitude can be quantitatively measured. By then comparing the amplitude of constriction between eyes, the presence of a relative afferent pupillary defect (RAPD) can be ascertained. Detection of an RAPD plays a crucial role in the diagnosis of many ocular diseases.
REC name
London - Central Research Ethics Committee
REC reference
17/LO/0105
Date of REC Opinion
2 Mar 2017
REC opinion
Further Information Favourable Opinion