Automated pupil measurement in glaucoma and other optic nerve diseases

• Research type

  Research Study

• Full title

  An assessment of the the RAPDx pupillometer investigating test-retest reliability, and strength of associations between relative afferent pupil defect magnitude and measures of structure and function in patients with different subtypes of glaucoma and other optic neuropathies.

• IRAS ID

  151528

• Contact name

  Mitchell Lawlor

• Contact email

  mitchell.lawlor@moorfields.nhs.uk

• Sponsor organisation

  Moorfields Eye Hospital

• Research summary

  Assessment of pupil function is an important part of examination in patients with diseases of the optic nerve. Traditional measurement of a relative afferent pupil defect (RAPD) has involved a qualitative assessment of pupil dysfunction by a trained observer. A new automated pupillometer is commercially available that can automatically quantify the magnitude of an RAPD. This study will investigate the test-retest variability of this instrument, as well as investigating whether there is an association between RAPD and measures of structure (optical coherence tomography) and measures of function (Humphrey visual field). These parameters will be investigated in 3 subgroups of patients with optic neuropathies, normal tension glaucoma, high pressure primary open angle glaucoma, and anterior ischaemic optic neuropathy.

• REC name

  East Midlands - Derby Research Ethics Committee

• REC reference

  14/EM/1011

• Date of REC Opinion

  6 Jun 2014

• REC opinion

  Favourable Opinion