Assessment of small bowel baseline impedance in healthy participants
Research type
Research Study
Full title
Assessment of antro-duodeno-jejunal motility, luminal flow and mucosal integrity in healthy participants: A study using high resolution manometry and impedance
IRAS ID
224349
Contact name
Daniel Sifrim
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
Abnormalities in movements of digestive tracts can be present indigestion not caused by stomach ulcers(non-ulcer dyspepsia), high level of bacteria growing in the small intestine) and chronic pseudo-obstruction of the intestine. This abnormal movements can affect transport of chime (semi-fluid mass of partly digested food), that can lead to vomiting, diarrhoea, abdominal pain and bloating. While it is well known that small intestinal disorders may be associated with damage of intestinal lumen, recent studies in patients with indigestion have also reported microscopic damage in the duodenum, which is situated just beyond the stomach, causing impaired function. Therefore, a comprehensive assessment of these disorders, should include evaluation of motility (movement), flow, and tissue damage.
Manometry is a test that assesses if the muscles of the digestive tract are working properly, detecting pressure changes within the digestive tracts. Manometry of the stomach and small intestine have been used to assess motor abnormalities. Although manometry detects patterns of movements, it provides little information regarding intestinal clearance and transit. Therefore, an accurate assessment of both movements and intra-luminal clearance/transport is needed.
Multichannel intra-luminal impedance (MII) is a technique that can detect flow in the digestive tracts. Assessment of impedance, whilst at rest, provides assessment of tissue damage.
Having been successfully employed to study oesophageal (gullet) and anorectal (anus and rectum) movements, high-resolution manometry (HRM which uses many more pressure sensors than usual) has also been applied to investigate motility in the digestive tract. A combination of HRM with MII is currently used to assess movement, transport of contents of the gullet and resting impedance, in patients with suspected intestinal disorders. However there are no normal data obtained from healthy volunteers. The purpose of this project is to collect normal data in order to compare healthy values with those in disease.REC name
London - Central Research Ethics Committee
REC reference
17/LO/0701
Date of REC Opinion
2 Jun 2017
REC opinion
Further Information Favourable Opinion