Assessing ventilation pre and post airway clearance techniques in PCD
Research type
Research Study
Full title
Assessing the effects of airway clearance interventions in young people with Primary Ciliary Dyskinesia using ventilation MRI scans: a proof of concept study.
IRAS ID
198572
Contact name
Jim Wild
Contact email
Sponsor organisation
Sheffield Children's Hospital
Duration of Study in the UK
0 years, 3 months, 1 days
Research summary
Background to the research
Primary Ciliary Dyskinesia (PCD) is an inherited condition affecting the lungs from birth. In PCD mucus builds up and blocks small airways causing repeated chest infections, progressive lung damage, and failure of their respiratory system. To manage PCD and prevent deterioration airway clearance techniques (ACTs) are used
to move and clear mucus from the airways. ACTs include breathing techniques, blowing through devices to open the airways and inhaling medicines to make mucus less sticky. Each person with PCD is recommended an ACT regimen tailored to their needs, to complete twice daily at home. There is minimal research into ACTs in PCD,
patient and public involvement (PPI) work has identified understanding and optimising the effects of ACTs as a research priority. Currently the measures available to assess ACTs are limited. This study uses a new and safe technique; magnetic resonance imaging (MRI) to take pictures of gas inside the lungs. In PCD, this technique has
shown areas where mucus is blocking the airways even in people with mild disease. In other conditions MRI has been able to show changes caused by ACTs.
Aims of the research
This study aims to measure the effects of ACTs in young people with PCD using the most advanced new tests of lung function.
Design and methods used
The study aims to observe patient’s usual care with the additional information provided by lung imaging. People aged over 5 with PCD will be invited.
This will involve attending one appointment in Sheffield. On the day they will have:
• Simple breathing tests and the first MRI (usual care)
• They will complete their usual ACT
• We will repeat the MRI and breathing tests again (extra assessments)REC name
North West - Liverpool Central Research Ethics Committee
REC reference
18/NW/0595
Date of REC Opinion
24 Oct 2018
REC opinion
Further Information Favourable Opinion