assessing nerve regernation through motor renervation assessment
Research type
Research Study
Full title
An assessment of Nerve regeneration through muscle motor unit regeneration.
IRAS ID
231428
Contact name
T Quick
Contact email
Sponsor organisation
Royal National orthopaedic hospital
Duration of Study in the UK
0 years, 11 months, 5 days
Research summary
We are working to establish clinical methods to assess nerve regeneration in a controlled manner.
After nerve injury nerves regenerate and arrives at the muscle leading to the appearance of Motor units (MUs) which can be assessed using a method using neurophysilogy. This involves stimulating a nerve and recording the response of the muscle that it innervates.
In this pilot we specifically wish to assess if our presumptions on the arrival of Motor Units (MUs) in renervated muscle are valid. That is to say that the speed of regernation, the quality and quantity of the regenerating axons can be assessed by neurophysilogy.
Motor unit number estimation is a novel method that can assess the number of motor units arriving at a muscle but there is no published work on the arrival of MUs in human renervated muscle. This may be due to the fact that MUNE while widely used in the medical research environment is not discussed in surgical literature.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
17/WM/0438
Date of REC Opinion
20 Dec 2017
REC opinion
Further Information Favourable Opinion